Skip Navigation



European Journal of Echocardiography Advance Access published online on March 31, 2009
European Journal of Echocardiography, doi:10.1093/ejechocard/jep026
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
10/5/647    most recent
jep026v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Stefanidis, A.
Right arrow Articles by Papasteriadis, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stefanidis, A.
Right arrow Articles by Papasteriadis, E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org

Left ventricular anatomical and functional changes with ageing in type 2 diabetic adults

Alexander Stefanidis1,*, Stavros Bousboulas2, John Kalafatis1, Kyriaki Baroutsi1, Panagiotis Margos1, Komninos Komninos1, Stavros Pappas2 and Evaggelos Papasteriadis1

1 1st Department of Cardiology, General Hospital of Nicea, 3 D. Mantouvalou Street, 184-54 Piraeus, Greece
2 3rd Department of Internal Medicine, Diabetic Center, General Hospital of Nicea, Piraeus, Greece

Received 28 November 2008; accepted after revision 7 March 2009.

* Corresponding author. Tel: +30 213 2077306; fax: +30 210 4924472. E-mail address: plato203{at}yahoo.com


  Abstract

Aims: Previous studies indicate that diabetic patients show evidence of coexisting systolic and diastolic myocardial dysfunction when examined by new echocardiographic techniques. Yet, there is no systematic investigation of the serial age-related changes of left ventricular anatomy and function in this patient population.

Methods and results: One hundred and sixty type 2 diabetic patients and 110 non-diabetic controls, all with no evidence of heart disease, were studied. The participants were stratified into four distinct age-groups (A: <46, B: 46–60, C: 61–75, and D: >75 years) and underwent full echocardiographic examination. Conventional systolic and diastolic parameters were similar between the study groups. However, tissue Doppler imaging examination revealed an impaired systolic and diastolic longitudinal myocardial function in diabetic patients vs. controls, although these differences were not noticed within the youngest age-group. Diastolic dysfunction was established concomitantly in both diabetic and control subjects in age-group B. In contrast, diabetic patients showed an earlier induction of myocardial systolic dysfunction, evidenced by significantly lower average systolic longitudinal myocardial velocity in age-group B. Independent predictors of systolic myocardial dysfunction were age, glycated haemoglobin, and systemic blood pressure.

Conclusion: Type 2 diabetic patients demonstrate an early and concomitant induction of systolic and diastolic myocardial dysfunction as a preclinical manifestation of diabetic cardiomyopathy.

Keywords: Diabetic cardiomyopathy; Tissue Doppler imaging


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.