Skip Navigation



European Journal of Echocardiography Advance Access published online on August 31, 2007
European Journal of Echocardiography, doi:10.1016/j.euje.2007.06.008
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
9/4/466    most recent
j.euje.2007.06.008v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Pinamonti, B.
Right arrow Articles by Sinagra, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pinamonti, B.
Right arrow Articles by Sinagra, G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Incremental prognostic value of restrictive filling pattern in hypertrophic cardiomyopathy: a Doppler echocardiographic study

Bruno Pinamonti*, Andrea Di Lenarda, Gaetano Nucifora, Dario Gregori, Andrea Perkan and Gianfranco Sinagra

Cardiovascular Department, Azienda Ospedaliero-Universitaria ‘Ospedali Riuniti’ di Trieste, Trieste, Italy

Received 14 February 2007; accepted after revision 20 June 2007.

* Corresponding author. Cardiovascular Department, Ospedale di Cattinara, ‘Ospedali Riuniti’ and University of Trieste, Strada di Fiume, 447, 34100 Trieste, Italy. Tel: +39403994837; fax: +39403994878. E-mail address: bpinamonti{at}hotmail.com (B. Pinamonti).


  Abstract

Aim: To study frequency and incremental prognostic value of restrictive filling pattern (RFP) in hypertrophic cardiomyopathy (HCM).

Methods and results: Eighty-seven consecutive HCM patients (64% men, mean age 45 ± 19 years) underwent physical and Doppler echocardiographic evaluation at our centre from March 1993 to February 2001. Mean length of follow-up was 96 ± 54 months. RFP was found in 14 patients (16%) at index evaluation. Patients with RFP had higher NYHA class, more frequent signs of heart failure and lower left ventricular ejection fraction (P = 0.018, P = 0.002 and P = 0.001, respectively). During follow-up, cardiac death plus heart transplantation was significantly higher in HCM patients with RFP than in those without RFP (P = 0.0001). NYHA class (HR = 5.95, 95% CI: 1.34–26.38, P = 0.019), indexed left atrial diameter (HR = 1.68, 95% CI: 1.01–2.82, P = 0.047) and RFP (HR = 2.94, 95% CI: 1.25–6.88, P = 0.01) were selected as predictors of cardiac death or heart transplantation in a multivariate proportional hazard model. The AUC of ROC curve from multivariate regression models for predicting adverse outcome significantly improved from 0.76 considering only NYHA class to 0.84 after inclusion of RFP and indexed left atrial diameter (P = 0.01).

Conclusions: RFP is rare, but not exceptional, in HCM. Echo-Doppler evaluation of filling pattern confers additional prognostic power to clinical stratification.

Keywords: Hypertrophic cardiomyopathy; Diastole; Echocardiography; Prognosis


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.