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European Journal of Echocardiography 2007 8(2):94-101; doi:10.1016/j.euje.2006.02.003
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Copyright © 2006, The European Society of Cardiology

Can the left ventricular early diastolic tissue-to-blood time interval be used to identify a normal pulmonary capillary wedge pressure?

Cecilia Wallentin Gurona,*, Anita Perssona, Ronny Wikha and Kenneth Caidahla,b

aDepartment of Clinical Physiology, Sahlgrenska University Hospital/Östra, Smörslottsgatan 1, SE-416 85 Göteborg, Sweden
bDepartment of Clinical Physiology, Karolinska Institute, Stockholm, Sweden

Received 3 October 2005; received in revised form 29 January 2006; accepted after revision 9 February 2006.

* Corresponding author. Tel.: +46 703 127772; fax: +46 31 7780551. c.wallentin{at}home.se


  Abstract

The pulsed Doppler early diastolic left ventricular (LV) tissue (e)–blood (E) onset temporal relationship (e–E) is suggested to predict pulmonary capillary wedge pressure (PCWP), through the formulas: tau=32+0.7(e–E) and PCWP=LV end-systolic pressurexe–IVRT/tau. Small changes/errors in E could influence the quotient IVRT/tau by oppositely affecting IVRT and e–E. At rest in 50 healthy individuals we noted: e–E: 2±14ms; IVRT: 89±17ms; calculated tau: 33±10ms; and PCWP: 9±9mmHg (>12mmHg in 28%). Non-pharmacological preload alterations in 14 individuals rendered an intraindividual ‘PCWP’-fluctuation of up to 40mmHg. This application may therefore not be clinically robust.

Keywords: Pulsed tissue Doppler; Echocardiography; Left ventricular; Time interval; Diastolic function; Pulmonary capillary wedge pressure


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