Copyright © 2005, The European Society of Cardiology
New generation 3-dimensional echocardiography for left ventricular volumetric and functional measurements: Comparison with cardiac magnetic resonance
Department of Cardiology, Academic Unit, The University of Hull, Castle Hill Hospital, Castle Road, Cottingham, Kingston-upon-Hull HU16 5JQ, UK
Received 15 March 2005; received in revised form 21 September 2005; accepted after revision 30 September 2005.
* Corresponding author. Tel.: +44 1482 624144; fax: +44 1482 624071.
n.p.nikitin{at}hull.ac.uk
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Abstract |
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Aims Non-invasive assessment of left ventricular (LV) structure and function is important in the evaluation of cardiac patients. This study was designed to test the accuracy and reproducibility of new generation 3-dimensional echocardiography (3DE) in measuring volumetric and functional LV indices as compared with current "gold standard" of non-invasive cardiac imaging, cardiac magnetic resonance (CMR).
Methods and results Sixty-four subjects with good acoustic windows, including 40 cardiac patients with LV ejection fraction (EF)<45%, 14 patients with EF>45% and 10 normal volunteers underwent 3DE using a commercially available Philips Sonos 7500 scanner equipped with a matrix phase-array x4 xMATRIX transducer, and CMR on a 1.5T Signa CV/i scanner (GE Medical Systems). Volumetric assessment was performed with analytical 4D-LV-Analysis software (TomTec) for 3DE and MRI-Mass software (Medis) for CMR.
We found no significant differences in LV end-diastolic volume (EDV), end-systolic volume (ESV) and EF with excellent correlations between the indices measured using 3DE and CMR (r=0.97, r=0.98, and r=0.94, respectively). Bland–Altman analysis showed bias of 7ml for EDV, 3ml for ESV and –1% for EF with 3DE with corresponding limits of agreement (2SD) of 28ml, 22ml and 10%, respectively. Intraobserver and interobserver variabilities were for EDV: 3% and 4% (3DE) vs 2% and 2% (CMR), for ESV: 3% and 6% (3DE) vs 2% and 3% (CMR), and for EF: 4% and 4% (3DE) vs 2% and 4% (CMR), respectively.
Conclusion New generation 3DE provides accurate and reproducible quantification of LV volumetric and functional data in subjects with good acoustic windows as compared with CMR.
Keywords: Imaging; Echocardiography; Left ventricular function; Magnetic resonance imaging
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