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European Journal of Echocardiography 2007 8(1):48-49; doi:10.1016/j.euje.2006.06.008
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Copyright © 2007, The European Society of Cardiology

Atrial septal endocarditis

Andrew R.J. Mitchell*, Paul Leeson, Jonathan Timperley, Saul G. Myerson, Harald Becher and Jonathan Goldman

Department of Echocardiography, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom

Received 11 April 2006; received in revised form 5 June 2006; accepted after revision 15 June 2006.

* Corresponding author. Tel.: +44 1865 220981; fax: +44 1865 221432. mitcharj{at}doctors.org.uk


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Atrial septal endocarditis can occur as an isolated event or in association with valvular endocarditis. It is also reported following percutaneous device closure of atrial septal defects. We present the echocardiography findings from a young man presenting with endocarditis of an abnormal mitral valve in whom endocarditis was demonstrated associated with an atrial septal defect.

Keywords: Endocarditis; Atrial septal defect; Echocardiography

A 24-year-old man presented with a short history of fever and swollen lower limbs. Physical examination revealed signs of significant mitral regurgitation and blood cultures grew Streptococcus viridans. Transoesophageal and transthoracic echocardiography demonstrated prolapse of the mid-portion (P2) of the posterior mitral valve leaflet with severe mitral regurgitation. There was a 9mm by 9mm vegetation attached to the abnormal leaflet (Fig. 1). Echocardiography also identified a 10mm secundum atrial septal defect (Fig. 2) with left to right shunting of the mitral regurgitation jet through the defect (Fig. 3). Along the inferior left atrial side of the septal defect were multiple small mobile masses in keeping with endocarditis of the atrial septum (Figs. 4 and 5). The patient was treated with a four-week course of antibiotics with rapid clinical improvement and resolution of the vegetations. One month later the patient underwent mitral valve repair and closure of the atrial septal defect without complication.


Figure 1
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Figure 1 Transoesophageal long-axis echocardiography of the mitral valve demonstrating a large vegetation attached to the posterior mitral valve leaflet LA=left atrium, LV=left ventricle.

 


Figure 2
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Figure 2 Transoesophageal short-axis view at the level of the aortic valve showing the atrial septal defect (ASD). LA=left atrium, RA=right atrium.

 


Figure 3
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Figure 3 Apical four-chamber transthoracic echocardiography demonstrating shunting of mitral regurgitation through the atrial septal defect (ASD). LA=left atrium, LV=left ventricle, RV=right ventricle.

 


Figure 4
Figure 4
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Figures 4 and 5 Transoesophageal view of the atrial septum showing vegetations along the left atrial surface of the septum. ASD=atrial septal defect, LA=left atrium, RA=right atrium.

 
Atrial septal endocarditis is uncommon but has been reported in patients in isolation and in association with endocarditis of other heart valves.1–4 Endocarditis of the atrial septum is also recognised following percutaneous closure of atrial septal defects.5,6 In patients presenting with valvular endocarditis it is important to consider transoesophageal echocardiography to closely examine all cardiac valves in addition to excluding co-existent congenital abnormalities.


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Supplementary data associated with this article can be found in the online version, at 10.1016/j.euje.2006.06.008


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  1. Bush R.T. Staphylococcal endocarditis with atrial septal defect. Report of a fatal case with a review of treatment. NZ Med J (1959) 58:444–449.[Medline]
  2. Cay S., Korkmaz S. Tricuspid valve vegetation in a chronic renal failure patient with an ostium secundum type atrial septal defect after placement of a peripheral catheter. Anadolu Kardiyol Derg (2005) 5(3):261.[Medline]
  3. Aliaga L., Santiago F.M., Marti J., Sampedro A., Rodriguez-Granger J., Santalla J.A. Right-sided endocarditis complicating an atrial septal defect. Am J Med Sci (2003) 325(5):282–284.[CrossRef][Web of Science][Medline]
  4. Rahman A., Burma O., Felek S., Yekeler H. Atrial septal defect presenting with Brucella endocarditis. Scand J Infect Dis (2001) 33(10):776–777.[CrossRef][Web of Science][Medline]
  5. Balasundaram R.P., Anandaraja S., Juneja R., Choudhary S.K. Infective endocarditis following implantation of amplatzer atrial septal occluder. Indian Heart J (2005) 57(2):167–169.[Medline]
  6. Bullock A.M., Menahem S., Wilkinson J.L. Infective endocarditis on an occluder closing an atrial septal defect. Cardiol Young (1999) 9(1):65–67.[Web of Science][Medline]

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