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European Journal of Echocardiography Advance Access originally published online on June 11, 2008
European Journal of Echocardiography 2008 9(5):575-577; doi:10.1093/ejechocard/jen181
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Polishing the diastolic dysfunction measurement stick

M. Louis Handoko and Walter J. Paulus*

Laboratory of Physiology, Institute for Cardiovascular Research (ICaR), VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands

Received 4 May 2008; accepted after revision 18 May 2008; online publish-ahead-of-print 11 June 2008.

* Corresponding author. Tel: +31 20 4448110; fax: +31 20 4448255. E-mail address: wj.paulus@vumc.nl

The first 150 words of the full text of this article appear below.

Diastolic heart failure currently accounts for more than 50% of all heart failure cases in Western societies.1 Because of normal left ventricular (LV) systolic function, diastolic heart failure is mainly attributed to diastolic LV dysfunction evident from slow LV relaxation and high diastolic LV stiffness.2,3 High diastolic LV stiffness is the most important cause of the repetitive heart failure episodes occurring in these patients,4 while high arterial elastance,5 atrial remodelling,6 and impaired chronotropic7 or vasomotor8 responses are additional contributors. Because of the pathophysiological importance of diastolic LV dysfunction, all previous diagnostic guidelines for diastolic heart failure considered evidence of diastolic LV dysfunction to be essential for the diagnosis.9–11 The recently updated diagnostic guidelines for diastolic heart failure provided by the Echocardiography and Heart Failure Associations of the European Society of Cardiology12 continued to adhere to this principle and required three conditions to be simultaneously satisfied for the diagnosis . . . [Full Text of this Article]


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