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European Journal of Echocardiography Advance Access published online on February 12, 2008
European Journal of Echocardiography, doi:10.1093/ejechocard/jen035
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Published on behalf of the European Society of Cardiology All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Strain rate imaging pre- and post-percutaneous coronary intervention: a potential role in the objective detection of ischaemia in exercise stress echocardiography

J. Thambyrajah*, K. Vijayalakshmi, R.J. Graham, A.J. Turley, M.A. de Belder and M.J. Stewart

Cardiothoracic Division, The James Cook University Hospital, Middlesbrough TS4 3BW, UK

Received 18 November 2007; .

* Corresponding author. Tel: +44 1642 850850; fax: +44 1642 282408. E-mail address: jeet.thambyrajah{at}stees.nhs.uk


  Abstract

Aims: To determine the feasibility of strain rate imaging (SRI) in the objective detection of exercise-induced ischaemia.

Methods and results: Sixteen patients undergoing elective percutaneous coronary intervention (PCI) underwent treadmill exercise stress echocardiography (ESE) pre- and post-PCI. Measurement of systolic SRI parameters was attempted in all myocardial segments at baseline, peak stress, and in recovery. Segments were divided into those supplied by target (Group 1) and non-target vessels (Group 2).

Percutaneous coronary intervention was successful in all patients. In Group 1, there was no significant difference in post-systolic strain rate (SRps) at baseline or at peak stress but there was significantly greater SRps pre-PCI compared with post-PCI at 30 min into recovery (–0.37 ± 0.53 vs. –0.07 ± 0.44 s–1, P = 0.004). There were similar findings with the SRps index [ratio of SRps:peak systolic strain rate (SRsys)]. Group 2 segments did not demonstrate any significant differences in SRI parameters pre- and post-PCI. At peak exercise pre-PCI, Group 1 segments had significantly delayed time to SRsys compared with Group 2 (0.12 ± 0.05 vs. 0.09 ± 0.05 s, P = 0.013), a difference that was abolished post-PCI.

Conclusion: This suggests a potential role for SRI in the objective detection of exercise-induced ischaemia by echocardiography at peak stress and during recovery at the time of improved image quality.

Keywords: Strain rate imaging; Exercise stress echocardiography; Percutaneous coronary intervention


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