Skip Navigation



European Journal of Echocardiography Advance Access published online on February 22, 2008
European Journal of Echocardiography, doi:10.1093/ejechocard/jen003
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
9/5/605    most recent
jen003v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Kiotsekoglou, A.
Right arrow Articles by Child, A. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kiotsekoglou, A.
Right arrow Articles by Child, A. H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published on behalf of the European Society of Cardiography. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Early impairment of left ventricular long-axis systolic function demonstrated by reduced atrioventricular plane displacement in patients with Marfan syndrome{dagger}

Anatoli Kiotsekoglou1, Abhay Bajpai1, Bart H. Bijnens1, Venedictos Kapetanakis1, George Athanassopoulos2, James C. Moggridge1, Mike J. Mullen3, Dariush K. Nassiri1, John Camm1, George R. Sutherland1 and Anne H. Child1,*

1 Department of Cardiac and Vascular Sciences, St George's University of London, Cranmer Terrace, London SW17 0RE, UK
2 Onassis Cardiac Surgery Centre, 176 74 Kallithea, Athens, Greece
3 Royal Brompton and Harefield Hospital, NHS Trust, London SW3 6NP, UK

Received 20 July 2007; accepted after revision 23 October 2007.

* Corresponding author. Tel: + 44 208 7255248; fax: + 44 208 7252653. E-mail address: achild{at}sgul.ac.uk


  Abstract

Aims: Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the fibrillin-1 (FBN1) gene. It has been observed that FBN1 deficient mice have reduced left ventricular (LV) systolic function which is correlated to increased transforming growth factor-β activity. This study aimed to ascertain LV functional abnormalities in MFS patients using M-mode and tissue Doppler imaging (TDI).

Methods and results: In 66 (15–58 years) MFS patients and 61 normal controls, ejection fraction (EF) was evaluated by Simpson's biplane method. Atrioventricular plane displacement (AVPD) obtained from five mitral annular regions was also assessed using M-mode and TDI techniques. To overcome limitations associated with conventional M-mode echocardiography, anatomical and colour anatomical M-mode were also utilized.

Ejection fraction was significantly reduced in MFS patients when compared to controls (66.3 ± 0.74 vs. 71.9 ± 0.56, P < 0.001), although it was within the normal range. M-mode and TDI AVPD measurements obtained from lateral, septal, inferior, anterior and posterior mitral annular regions were also significantly reduced in MFS patients in comparison to controls (P <0.001, for all measurements).

Conclusion: Left ventricular long-axis systolic function is significantly reduced in MFS patients. This data suggests that LV function should be monitored in MFS and appropriate treatment applied if necessary.

Keywords: Marfan syndrome; Left ventricular systolic function; Atrioventricular plane displacement; Long-axis function; Tissue Doppler imaging

{dagger} This study was performed at St George's University of London and St George's Hospital NHS Trust, London, UK.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.