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European Journal of Echocardiography 2008 9(2):241-249; doi:10.1016/j.euje.2007.03.044
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2007. For permissions please email: journals.permissions@oxfordjournals.org

The impact of aging on left ventricular longitudinal function in healthy subjects: a pulsed tissue Doppler study

Pasquale Innelli, Ruben Sanchez, Francesco Marra, Roberta Esposito and Maurizio Galderisi*

Division of Cardioangiology with CCU, Department of Clinical and Experimental Medicine, Federico II University Hospital, Block 1, Via S. Pansini 5, 80131 Naples, Italy

Received 17 March 2007; accepted after revision 25 March 2007; online publish-ahead-of-print 25 June 2007.

* Corresponding author. Tel: +39 081 746 2145; fax: +39 081 546 6152. E-mail address: mgalderi{at}unina.it(M. Galderisi).


  Abstract

Aims: To evaluate the influence of age on average values of pulsed tissue Doppler recorded at the septal and lateral mitral annulus in a population of healthy subjects and to propose reference values according to different age decades.

Methods and results: Two hundred and forty-six healthy subjects (M/F = 160/86, mean age 40.9 years) underwent Doppler-echocardiography and pulsed tissue Doppler of the septal and lateral mitral annulus. Sm, Em, Am peak velocities were measured at both the annular sides and average values obtained. The ratio of transmitral E peak velocity and average Em peak velocity (lateral Em + septal Em/2) was calculated as an index of left ventricular filling pressure. The population was divided into seven age decades: 10–19, 20–29, 30–39, 40–49, 50–59, 60–69 years and >70 years. Em was progressively reduced and Am increased with increasing age at both the annular sides as well as average values. Sm reduction with advancing age was significant only at the lateral mitral annulus and as average values. Average E/Em ratio was particularly higher in the last three age decades. By multilinear regression analyses, age was the main independent predictor of average Em, Am and E/Em ratio, while heart rate was the most important contributor to average Sm, with the additional contribution of age.

Conclusions: Aging shows an independent impact on average tissue Doppler indexes of septal and lateral mitral annulus in normal subjects. Our data also provide reference values of tissue Doppler average variables for age decades.

Keywords: Aging; Pulsed tissue Doppler; Doppler echocardiography; Left ventricular function; Left ventricular filling pressure


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