Ventricular septal rupture following abciximab infusion
Department of Cardiology, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK
Received 27 July 2006; accepted after revision 29 August 2006; online publish-ahead-of-print 11 October 2006.
* Corresponding author. Tel: + 44 01865 228934; fax: +44 01865 220585. E-mail address: ranjitarnold{at}yahoo.co.uk
| Abstract |
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Ventricular septal rupture is a rare complication of myocardial infarction. Despite a significant reduction in its incidence with reperfusion therapy, thrombolysis has been implicated in the pathogenesis of septal rupture. There is little information regarding the impact of glycoprotein IIb–IIIa receptor blockers on ventricular septal rupture. We report a case of rupture of the ventricular septum occurring after treatment with the glycoprotein IIb–IIIa receptor blocker abciximab, in the absence of thrombolysis.
Keywords: Ventricular septal defect; Abciximab; Myocardial infarction; Surgical repair