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European Journal of Echocardiography 2008 9(1):34-39; doi:10.1016/j.euje.2007.02.007
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2007. For permissions please email: journals.permissions@oxfordjournals.org.

Tissue Doppler imaging describes diastolic function in men prone to develop hypertension over twenty years

A. Strand1,*, S.E. Kjeldsen1, H. Gudmundsdottir2, I. Os2, G. Smith1 and R. Bjørnerheim1

1 Department of Cardiology, Ullevaal University Hospital, Oslo, Norway
2 Department of Nephrology, Ullevaal University Hospital, Oslo, Norway

Received 29 November 2006; accepted after revision 14 February 2007; online publish-ahead-of-print 24 April 2007.

* Corresponding author. Department of Cardiology, Ullevaal University Hospital, Kirkeveien 166, N-0407 Oslo, Norway. Tel: +47 22 119 199; fax: +47 22 119 181. E-mail address: a.h.strand{at}medisin.uio.no


  Abstract

Aims: Hypertension is one of several risk factors of cardiovascular disease and is associated with left ventricular (LV) systolic and diastolic dysfunction. A method for reliably detecting the onset of LV dysfunction before transition to irreversible damage of the myocardium would be of crucial importance in subjects with essential hypertension.

Methods and results: Subjects with clear differences in BP level, development and duration of the hypertensive disease were examined at the age of 60 yrs: normotensives (n = 17), new hypertensives who developed hypertension over a 20 year period (n = 15) and hypertensives (n = 19). Relationships between conventional echocardiographic and tissue velocities imaging (TVI) parameters compared to LV parameters, and TVI as an estimate of LV function were explored. E'Lat (TVI peak early diastolic velocity) (P = 0.006) and E/E'Lat (P = 0.002) demonstrated differences in diastolic function between the groups. There were no significant differences regarding systolic myocardial velocities. E'Lat correlated to S'Lat (TDI peak systolic velocity) (r = 0.32, P = 0.026) and was independently predicted by S'Lat (R2 = 0.24, P = 0.025) in multivariate analysis. E'Lat correlated negatively to LV mass index (r = –0.34, P = 0.012), also in multivariate regression analysis (R2 = 0.12, P = 0.032).

Conclusions: Myocardial diastolic velocities and mitral flow to annulus velocity ratio differentiated LV function between the hypertensive and normotensive groups. The parameters probably reflect changes in relaxation, recoil and contraction and parallel changes in LV mass index.

Keywords: Tissue velocities imaging; LV function; LV mass; Hypertension


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