Copyright © 2007, The European Society of Cardiology
Predictive value of local and core laboratory echocardiographic assessment of cardiac function in patients with chronic stable angina: The ACTION study
aCardiovascular Medicine, Alfred Hospital, Melbourne, Victoria, Australia
bDivision of Cardiology, Vestfold Hospital, Toensberg, Norway
cSOCAR Research, Nyon, Switzerland
dDivision of Cardiology, University Health Network and Mount Sinai Hospitals, Toronto, Ontario, Canada
eCardiac Medicine, Imperial College, London, UK
fDepartment of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
Received 2 August 2006; received in revised form 5 February 2007; accepted after revision 14 February 2007.
a.dart{at}alfred.org.au
* Corresponding author. The Heart Centre, Alfred Hospital, Commercial Road, Melbourne, Victoria 3004, Australia. Tel.: +61 3 9076 3232; fax: +61 3 9076 2495.
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Abstract |
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Aims To evaluate the relationship between echocardiographic cardiac function and outcome in patients with stable symptomatic angina.
Methods Baseline echo left ventricular ejection fraction and volume data measured in a central laboratory was available for 7016 patients (92% of the total) participating in the ACTION trial (A Coronary disease Trial Investigating Outcome with Nifedipine GITS). Ejection fraction was also measured by investigators. Evaluation of the different echocardiographic variables was based on adjusted hazard ratios comparing the unfavourable limit of the 90% range of the variable concerned to the favourable limit.
Results The centrally measured ejection fraction was the most powerful predictor of all-cause death (adjusted hazard ratio=2.5), myocardial infarction, any stroke or transient ischaemic attack and overt heart failure (adjusted hazard ratio=4.5). The addition of either end systolic volume or end diastolic volume to ejection fraction did not materially affect the power of prediction. Compared to the central ejection fraction measurement, the investigator-measured ejection fraction was a less powerful predictor for all outcomes considered.
Conclusion Routine echocardiography carefully analysed by standardised methods provides useful prognostic information in patients with stable angina, including for total mortality.
Keywords: Coronary artery disease; Angina; Left ventricular function; Echocardiography; Prognosis
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