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European Journal of Echocardiography 2007 8(4):247-251; doi:10.1016/j.euje.2006.02.002
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Copyright © 2006, The European Society of Cardiology

Hydroxychloroquine-induced restrictive cardiomyopathy: Correlation between clinical, Echocardiographic and pathologic findings

John Cotroneoa, Khaled M. Sleikb, E. Rene Rodriguezc and Allan L. Kleind,*

aDepartment of Cardiology, The Northern Hospital, Melbourne, Australia
bDepartment of Cardiology, Robinson Memorial Hospital, Ravenna, OH 44266, USA
cDepartment of Anatomic Pathology, Cleveland Clinic, Cleveland, USA
dDepartment of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Avenue, Desk F15, Cleveland, OH 44195, USA

Received 22 December 2005; accepted after revision 1 February 2006.

* Corresponding author. Tel.: +1 216 444 3932; fax: +1 216 445 2309. kleina{at}ccf.org


  Abstract

Chloroquine (Hydroxychloroquine)-induced cardiomyopathy is a rare but potentially life-threatening condition. Cessation of the culprit drug, along with aggressive afterload reduction therapy, has been associated with halting of disease progress and even improvement in patients' clinical and histologic status. Echocardiography is a fundamental tool in the identification and assessment of patients with cardiomyopathy, with particular utility in the detailed assessment of biventricular systolic and diastolic function. It also provides an objective and non-invasive means of assessing treatment response. We present a case of a 51-year-old woman with hydroxychloroquine-induced restrictive cardiomyopathy and correlate clinical, echocardiographic and anatomic pathologic findings both at initial presentation and following treatment.

Keywords: Chloroquine; Hydroxychloroquine; Cardiomyopathy; Restrictive cardiomyopathy


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