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European Journal of Echocardiography 2007 8(1):30-36; doi:10.1016/j.euje.2005.12.009
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Copyright © 2005, The European Society of Cardiology

Brain natriuretic peptide plasma level is a reliable indicator of advanced diastolic dysfunction in patients with chronic heart failure

Angela Beatrice Scardovia,*, Claudio Colettaa, Nadia Aspromontea, Silvia Pernab, Manuela Greggia, Paola D'Errigoc, Augusto Sestilia and Vincenzo Cecia

aCardiology Department, S. Spirito Hospital, Lungotevere in Sassia 1, 00196 Rome, Italy
bCardiology Department, S. Andrea Hospital, Rome, Italy
cIstituto Superiore di Sanità, Rome, Italy

Received 6 August 2005; received in revised form 13 October 2005; accepted after revision 15 December 2005.

* Corresponding author. Tel.: +39 06 68352264; fax: +39 06 68354880. ab.scardovi{at}libero.it


  Abstract

The aim of the study was to determine the value of brain natriuretic peptide for the identification of diastolic dysfunction status in congestive heart failure.

We studied 204 patients with stable heart failure. Brain natriuretic peptide plasma levels were correlated with echocardiographic parameters of diastolic dysfunction. Diastolic dysfunction was classified as mild (abnormal echocardiographic relaxation pattern) and severe (pseudo-normal or restrictive pattern). A significant correlation between brain natriuretic peptide levels and the other parameters was detected.

Brain natriuretic peptide dosage, then, seems to be a reliable tool for the assessment of diastolic dysfunction status in patients with congestive heart failure.

Keywords: Brain natriuretic peptide; Heart failure; Doppler echocardiography; Diastole


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