Doppler myocardial imaging in adult male rats: Reference values and reproducibility of velocity and deformation parameters

doi:10.1016/j.euje.2006.03.009

European Journal of Echocardiography 2006 7(6):411-417; doi:10.1016/j.euje.2006.03.009

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Doppler myocardial imaging in adult male rats: Reference values and reproducibility of velocity and deformation parameters

Caroline Weytjens^a^,*, Bernard Cosyns^a, Jan D'hooge^c, Carole Gallez^b, Steven Droogmans^a, Tony Lahoute^b, Philippe Franken^b and Guy Van Camp^a

^aDepartment of Cardiology, University Hospital AZ VUB, Laarbeeklaan 101, 1090 Brussels, Belgium
^bDepartment of Nuclear Medicine, University Hospital AZ VUB, Laarbeeklaan 101, 1090 Brussels, Belgium
^cDepartment of Cardiology and Cardiac Imaging Research, University Hospital Gasthuisberg, Leuven, Belgium

Received 22 December 2005; received in revised form 7 March 2006; accepted after revision 19 March 2006.

^* Corresponding author. Tel.: +32 2 477 6312; fax: +32 2 477 6840. igwsc{at}az.vub.ac.be

Abstract

Aim Limited data are available about the use of Doppler myocardialimaging (DMI) in small animals. We intend to provide referencevalues for velocity, strain and strain rate in a large groupof healthy rats and studied the reproducibility and repeatabilityof these parameters.

Methods and results A total of 33 male Wistar rats (503±41g)underwent baseline transthoracic echocardiography with DMI ofthe anterior and inferior wall in a short-axis view using a13MHz linear probe. Adequate tissue Doppler measurements couldbe obtained in 30 rats. On average 10±4 consecutive cycleswere studied in post-processing using dedicated software (SPEQLE).Mean radial peak systolic velocity, strain and strain rate wererespectively –0.8±0.3cm/s, 38±8% and 9.1±2.0/sin the anterior wall and 3.1±0.6cm/s, 49±10% and13.7±3.7/s in the inferior wall. The reproducibilityand repeatability of the DMI measurements assessed in 10 ratswas good.

Conclusion DMI is feasible and reproducible in healthy rats.Establishing reference values opens new perspectives towardsthe use of strain and strain rate imaging in small rodents inthe assessment of myocardial diseases.

Keywords: Echocardiography; Rats; Doppler myocardial imaging; LV function; Reproducibility

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