Copyright © 2005, The European Society of Cardiology
The BNP assay does not identify mild left ventricular diastolic dysfunction in asymptomatic diabetic patients
aHeart Failure Centre, Cardiology Unit, Ospedale Civile, Via Sauro 26, San Donà di Piave, I-30027, VE, Italy
bDiabetes Outclinic, Ospedale Civile, San Donà di Piave, Italy
cHeart Failure Centre, Cardiology Unit, Santo Spirito Hospital, Rome, Italy
dHeart Failure Centre, Cardiology Unit, San Bonifacio Hospital, Italy
Received 7 November 2004; received in revised form 14 March 2005; accepted after revision 28 March 2005.
* Corresponding author. Tel.: +39 421 227537; fax: +39 421 227521. robertovalle{at}libero.it
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Abstract |
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Aims We examined the usefulness of BNP for screening for left ventricular (LV) diastolic dysfunction in a sample of type 2 diabetic patients, without structural heart disorder, who have never presented symptoms or signs of heart failure (HF).
Methods and results Seventy-six consecutive patients admitted to the Outpatient Diabetes Clinic were studied. Blood samples were analyzed using the Triage BNP fluorescence immunoassay (Biosite Diagnostics, La Jolla, CA, USA). Echocardiography examinations were performed, with no knowledge of the BNP value. A total of 39 patients out of 76 (51%) were diagnosed with LV diastolic dysfunction and 23 (30%) with LV hypertrophy. Of the patients with LV diastolic dysfunction, impaired relaxation and pseudonormal pattern accounted for 97 and 3% of the cases, respectively. BNP levels among subjects with LV diastolic dysfunction (26±22pg/ml, n=39) were not significantly different from patients with normal LV function (24±23pg/ml, n=37pg/ml; Mann–Whitney U-test, Z=–0.4, n.s.).
Conclusions Our data confirm alarmingly high prevalence of LV diastolic dysfunction in asymptomatic individuals with diabetes. Identification of patients with preclinical diabetic cardiomyopathy should be a research and clinical priority. BNP levels cannot be used to detect mild LV diastolic dysfunction in this subset of patients, which requires Doppler echocardiography to be detected.
Keywords: Diastolic dysfunction; B-type natriuretic peptide; Diabetes mellitus
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