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European Journal of Echocardiography 2005 6(5):367-375; doi:10.1016/j.euje.2005.01.007
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Copyright © 2005, The European Society of Cardiology

Evaluation of Tissue Doppler Tei index for global left ventricular function in mice after myocardial infarction: Comparison with Pulsed Doppler Tei index

Arnd Schaefer*, Gerd Peter Meyer, Denise Hilfiker-Kleiner, Birgit Brand, Helmut Drexler and Gunnar Klein

Department of Cardiology and Angiology, Medical School Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany

Received 18 August 2004; received in revised form 15 January 2005; accepted after revision 21 January 2005.

schaefer.arnd{at}mh-hannover.de

* Corresponding author. Tel.: +49 511 532 3841; fax: +49 511 532 3357.


  Abstract

Aim

The Pulsed Doppler Tei index is a parameter to evaluate combined systolic and diastolic function in humans. However, one major limitation is that the parameters of Pulsed Doppler Tei index cannot be measured within one cardiac cycle. Therefore, accuracy of the Pulsed Doppler Tei index may be affected by anesthesia induced heart rate variation in mice echocardiography. Tissue Doppler Imaging (TDI) enables us to measure both relaxation and contraction velocities simultaneously. Thus, the aim of our study was to validate TDI and Pulsed Doppler Tei index and their reproducibility in mice after experimental anterior myocardial infarction (MI).

Methods and Results

Pulsed Doppler Tei index and TDI Tei index were assessed before and 4 weeks after MI. Both parameters increased significantly after MI (Pulsed Doppler: 0.4±0.04 to 0.7±0.03; P < 0.001; TDI: 0.2±0.03 to 0.5±0.04; P < 0.0001). In addition, TDI Tei index showed a good correlation with ejection fraction and fractional shortening, and was indicated by better reproducibility than Pulsed Doppler Tei index.

Conclusion

Tissue Doppler Tei index is appropriate to characterize global left ventricular function in mice after MI.

Keywords: Mouse; Myocardial infarction; Echocardiography; Tissue Doppler; Pulsed Doppler; Tei index


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