Reference values from M-mode and Doppler echocardiography for normal Syrian hamsters

doi:10.1016/j.euje.2004.06.001

European Journal of Echocardiography 2005 6(1):41-46; doi:10.1016/j.euje.2004.06.001

This Article

	Full Text
	FREE Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Add to My Personal Archive
	Download to citation manager
	Request Permissions
	Disclaimer

Google Scholar

	Articles by Salemi, V. M.C.
	Articles by Mady, C.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Salemi, V. M.C.
	Articles by Mady, C.

Social Bookmarking

	What's this?

Reference values from M-mode and Doppler echocardiography for normal Syrian hamsters

Vera M.C. Salemi^a^,*, Angelina M.B. Bilate^b^,c, Félix J.A. Ramires^a, Michael H. Picard^d, Daniel M. Gregio^a, Jorge Kalil^b^,c^,e, Edécio Cunha Neto^b^,c^,e and Charles Mady^a

^aCardiomyopathies Unit, Heart Institute (InCor), University of São Paulo Medical School, Av Jandira 185 ap41B Moema, São Paulo 04080-000, Brazil
^bLaboratory of Immunology, Heart Institute (InCor), University of São Paulo Medical School, Av Jandira 185 ap41B Moema, São Paulo 04080-000, Brazil
^cInstitute for Investigation in Immunology/Millenium Institute, University of São Paulo Medical School, Av Jandira 185 ap41B Moema, São Paulo 04080-000, Brazil
^dCardiology Division and Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Boston, MA, USA
^eDivision of Clinical Immunology and Allergy, Department of Medicine, University of São Paulo Medical School, Av Jandira 185 ap41B Moema, São Paulo 04080-000, Brazil

Received 15 February 2003; received in revised form 5 February 2004; accepted after revision 2 June 2004.

^* Corresponding author. Tel./fax: +55-11-5031-3891. verasalemi{at}uol.com.br

Abstract

Aims: Echocardiography has recently been introduced to smallanimal research, allowing serial measurements of cardiac diseases.In addition, the hamster model has been increasingly used, asit mimics many human heart conditions. However, no referencerange of echocardiographic values reflecting normal left ventricular(LV) function exists for hamsters. The purpose of this studywas to provide one.

Methods and Results: The study group consisted of 118 10-week-old,female, Syrian golden hamsters, which underwent high-resolutionechocardiography. LV mass was calculated using the correctedcube formula, and LV systolic and diastolic function were assessedby fractional shortening and mitral inflow pulsed-wave Doppler,respectively. The myocardial performance index (MPI) measuredthe time spent in isovolumic activity and reflected both systolicand diastolic function. The mean±SD LV mass, fractionalshortening, and MPI were 0.19±0.04 g, 44.7±6.6%,and 0.39±0.1, respectively. E and A waves were differentiatedin 52% of all animals. Logistic regression adjusted with a cutoffof 378 bpm revealed that the risk of E/A wave fusion was 35times greater (95% CI: 12.6; 98.4) in animals with a heart rate>378 bpm.

Conclusion: This study documents echocardiographic characteristicsin normal Syrian hamsters, which can be used as control valuesfor future studies.

Keywords: Echocardiography; Ventricular function; Diastolic function; Hamster; Myocardial performance index

Add to CiteULike CiteULike Add to Connotea Connotea Add to Del.icio.us Del.icio.us What's this?

This article has been cited by other articles:

F. J. Ramires, V. M. Salemi, B. M Ianni, F. Fernandes, D. G Martins, A. Billate, E. Cunha NETO, and C. Mady
Aldosterone Antagonism in an Inflammatory State: Evidence for Myocardial Protection
Journal of Renin-Angiotensin-Aldosterone System, September 1, 2006; 7(3): 162 - 167.
[Abstract] [PDF]