Echocardiographic assessment of left ventricular midwall mechanics in spontaneously hypertensive rats

doi:10.1016/j.euje.2003.11.004

European Journal of Echocardiography 2004 5(3):169-175; doi:10.1016/j.euje.2003.11.004
© 2004 by European Society of Cardiology

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Echocardiographic assessment of left ventricular midwall mechanics in spontaneously hypertensive rats

Eduardo Manuel Escudero^*, María Cristina Camilión de Hurtado¹, Néstor Gustavo Pérez¹ and Ana Laura Tufare

Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, 60 y 120 (1900) La Plata, Argentina

Received 19 May 2003; received in revised form 14 November 2003; accepted after revision 24 November 2003.

cicmes{at}infovia.com.ar

^* Corresponding author. Tel.: +54-221-483-4833; fax: +54-221-425-5861.

Abstract

Aims: The present study was attempted to determine whether LVmidwall mechanics yielded different conclusions about LV systolicfunction than the assessment of endocardial LV mechanics byechocardiography in spontaneously hypertensive rats (SHR).

Methods and results: Thirty-six (18 Wistar normotensive (W),18 [SHR]) anesthetized rats were studied with two-dimensionaldirected M-mode echocardiogram to analyze LV structure (LV diameter,left ventricular wall thickness and LV mass [LVM]) and LV function(endocardial shortening [ES] and midwall shortening [MS]). Measurementswere made from three consecutive cardiac cycles on the M-modetracings.

There was no significant difference in LV dimension. LVM washigher in SHR (SHR: 595 ±111, W: 413 ± 83—p<0.01).ES was higher in SHR (SHR: 64.1±6%, w: 58.2±4%—p<0.01),whereas no significant difference was found in MS (SHR: 27±4%,W: 27.6±4%—ns). Twelve of 18 (66%) SHR showed endocardialshortening higher than normally predicted, compared with 3/18(16%) with observed enhanced MS (p<0.01).

Conclusion: These results suggest that the analysis of midwallmechanics by echo allows us to better understand the LV performancein SHR and that the exaggerated endocardial motion could notrepresent a really supernormal systolic performance.

Keywords: Left ventricular hypertrophy; Left ventricular function; Midventricular mechanics; Echocardiography

¹ Established Investigators of Consejo Nacional de InvestigacionesCientíficas y Técnicas (CONICET), Argentina.

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