© 2004 by European Society of Cardiology
Copyright © 2003, The European Society of Cardiology
Quantitative evaluation of myocardial perfusion in patients with revascularized myocardial infarction: comparison between intravenous myocardial contrast echocardiography and 99mTc-sestamibi single photon emission computed tomography
aDepartment of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
bDepartment of Cardiology, University Hospital RWTH, Aachen, Germany
Received 7 April 2003; received in revised form 11 August 2003; accepted after revision 13 August 2003.
* Corresponding author. Department of Cardiology, 6N-120, VU University Medical Center, P.O. Box 7057, NL-1007 MB Amsterdam, The Netherlands. Tel.: +31-20-4442244; fax: +31-20-4442446. gtj.sieswerda{at}vumc.nl
 |
Abstract |
|---|
Aims: This two-center study compared quantitative segmental perfusion mapping by intravenous myocardial contrast echocardiography (ivMCE) and scintigraphy (SPECT) in patients in the subacute phase of myocardial infarction (AMI).
Methods and results: Sixteen patients underwent ivMCE using 1:1 intermittent harmonic imaging 24 h after first AMI treated with PTCA and stenting. Apical contrast echocardiograms were obtained after the injections of SonazoidTM. Baseline-corrected peak myocardial videointensity (bcPMVI) was determined automatically in 16 segments. Resting 99mTc-sestamibi SPECT was performed within one day after ivMCE. SPECT images were reoriented matching the ivMCE views, and divided into the same segments as in ivMCE, from which mean count rate values were obtained. After exclusion due to artifacts or attenuation, 208/256 (82%) segments remained for analysis. Normalized SPECT count rate and bcPMVI correlated linearly: bcPMVI=1.237xSPECT–35; r = 0.74, p<0.0001. The relation remained identical in subgroup analysis based on participating center, echocardiographic view, perfusion territory, infarct zone, or function. Using SPECT as reference, mean bcPMVI was 77±19% in normal segments, 53±29% in mild–moderate defects and 25±18% in severe defects (p<0.001 for all comparisons).
Conclusion: The videointensity increase observed in quantitative ivMCE clearly correlated with SPECT tracer uptake. This further substantiates the use of ivMCE as a valid technique for myocardial perfusion imaging.
Keywords: AMI Acute Myocardial Infarction; ASE American Society of Echocardiography; LV Left Ventricle/Ventricular; TIMI Thrombolysis in Myocardial Infarction; (iv)MCE (intravenous) Myocardial Contrast Echocardiography; PTCA Percutaneous Transluminal Coronary Angioplasty; SPECT Single Photon Emission Computed Tomography
CiteULike 
Connotea 
Del.icio.us What's this?
Related articles in Eur J Echocardiogr:
- Myocardial contrast echocardiography: advantages of quantitative analysis
- Daniele Rovai
Eur J Echocardiogr 2004 5: 2-4.[Extract] [Full Text]
This article has been cited by other articles:
|
|
 |
|
  P. A. Dijkmans, R. Senior, H. Becher, T. R. Porter, K. Wei, C. A. Visser, and O. Kamp Myocardial Contrast Echocardiography Evolving as a Clinically Feasible Technique for Accurate, Rapid, and Safe Assessment of Myocardial Perfusion: The Evidence So Far J. Am. Coll. Cardiol., December 5, 2006; 48(11): 2168 - 2177. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Toledo, L. D. Jacobs, J. A. Lodato, J. M. DeCara, P. Coon, V. Mor-Avi, and R. M. Lang Quantitative diagnosis of stress-induced myocardial ischemia using analysis of contrast echocardiographic parametric perfusion images Eur J Echocardiogr, June 1, 2006; 7(3): 217 - 225. [Abstract] [Full Text] [PDF]
|
|