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European Journal of Echocardiography 2003 4(4):306-312; doi:10.1016/S1525-2167(03)00034-9
© 2003 by European Society of Cardiology
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Copyright © 2003, The European Society of Cardiology

Impact of Essential Hypertension and Diabetes Mellitus on Left Ventricular Systolic and Diastolic Performance{star}

N. H. Andersen1, S. H. Poulsen2, K. Helleberg3, P. Ivarsen4, S. T. Knudsen1 and C. E. Mogensen

1Department of Internal Medicine (Diabetes and Endocrinology), Aarhus University Hospital, Denmark
2Department of Cardiology, Aarhus University Hospital, Skejby, Denmark
3Department of Internal Medicine, Viborg County Hospital, Viborg, Denmark
4Department of Nephrology, Aarhus University Hospital, Skejby, Denmark

Received 18 December 2002; received in revised form 20 March 2003; received in revised form 20 March 2003; .


  Abstract

Aims: To investigate left ventricular systolic and diastolic function in patients with essential hypertension and diabetes mellitus associated with hypertension by the myocardial performance index (MPI).

Methods and Results: The study included 45 patients with essential hypertension, 45 patients with diabetes mellitus and hypertension and 45 normal subjects, who underwent a complete two-dimensional and Doppler echocardiography including assessment of the isovolumetric Doppler time intervals for the estimation of the Doppler-derived MPI.

The MPI was significantly higher in patients with essential hypertension and diabetes with hypertension, compared to controls (Essential hypertension=0.51±0.12; Diabetes=0.51±0.12 vs. controls 0.40±0.05, P=0.001). The isovolumetric contraction time was significantly prolonged in essential hypertension (56±26 msec vs. 40±17 msec, P<0.01 respectively) and among diabetes patients isovolumetric relaxation time was prolonged compared to normal subjects (100±20 ms vs. 87±16 ms, P<0.01, respectively). The index was not related to left ventricular mass, age or ejection fraction, but significantly correlated to E-wave deceleration time ({rho}=0.48, P<0.001)

Conclusions: The MPI is increased, in both essential hypertensive patients and diabetes patients with associated hypertension, despite normal ejection fraction.

Keywords: hypertension; diabetes; echocardiography; left ventricle; systole; diastole

{star} Project performed at the Department of Internal Medicine (Diabetes and Endocrinology), Aarhus University Hospital, Denmark.


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