© 2003 by European Society of Cardiology
Copyright © 2003, The European Society of Cardiology
Tissue Doppler echocardiography in patients with long QT syndrome
1Hopital Cardiologique, Services de Cardiologie et d'Explorations Fonctionnelles Cardiovasculaires, Lille, France
2Service de Cardiologie, Hôpital Lariboisière, 75010 Paris, France
3INSERM U523, Institut de Myologie, La Pitié- Salpêtrière, 75013 Paris, France
Received 22 November 2002; received in revised form 30 January 2003; accepted after revision 30 January 2003.
* Address correspondence to: Christine Savoye MD, Hopital Cardiologique, CHRU, Services de Cardiologie et d'Explorations Fonctionnelles Cardiovasculaires, Lille Cedex 59037, France. Fax: +33-3-20-44-44-14. c-savoye{at}chru-lille.fr
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Abstract |
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Background: Congenital long QT syndrome (LQTS) is a well-defined clinical entity associated with a high mortality among untreated patients. Tissue Doppler (TD) echocardiography that has been recently introduced, facilitates wall motion analysis. Therefore, to further characterize myocardial velocity abnormalities associated with LQTS, using TD and conventional echocardiography, we compared control subjects and LQTS patients.
Methods and results: Ten patients with mild LQTS and 14 control subjects were examined with standard and TD echocardiography. We studied myocardial velocities in basal and mid-segments of the septal, lateral, inferior and anterior walls. Peak velocity and time intervals were measured in each segment. We confirmed previously described M-mode abnormalities, demonstrated by an increase of the wall thickening time index. TD analysis demonstrated increased systolic and diastolic peak velocities for all segments in LQTS patients. Regional isovolumic relaxation time and systolic velocity half time (VHT) were significantly longer in LQTS group associated with a prolonged late systolic phase, resulting in a plateau morphology.
Conclusion: We demonstrated that TD allows the characterization of myocardial velocity abnormalities in LQTS patients. TD measurements could become part of the routine clinical evaluation for patients potentially affected by the LQTS as a new phenotypic marker.
Keywords: Tissue Doppler; echocardiography; long QT syndrome
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Eur J Echocardiogr 2003 4: 157-158.[Extract] [FREE Full Text]
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