European Journal of Echocardiography Advance Access originally published online on August 4, 2009
European Journal of Echocardiography 2009 10(8):933-940; doi:10.1093/ejechocard/jep099
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Improved prediction of outcome by contrast echocardiography determined left ventricular remodelling parameters compared to unenhanced echocardiography in patients following acute myocardial infarction
Department of Cardiovascular Medicine, Northwick Park Hospital, Northwick Park Institute of Medical Research, Harrow, UK
Received 21 June 2009; accepted after revision 29 June 2009; online publish-ahead-of-print 4 August 2009.
* Corresponding author: Consultant Cardiologist and Director of Cardiac Research, Department of Cardiology, Northwick Park Hospital, Harrow, Middlesex, HA1 3UJ, UK. Tel: +44 208 869 2547/2548; fax: +44 208 864 0075. E-mail address: roxysenior{at}cardiac-research.org
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Abstract |
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Aims: Contrast echocardiography has been shown to be a more accurate method of assessing left ventricular (LV) remodelling compared with unenhanced echocardiography after acute myocardial infarction (AMI). However, whether this translated into improved prediction of outcome is not known.
Methods and results: Accordingly, a total of 89 consecutive patients undergoing contrast echocardiography and unenhanced echocardiography 7 to 10 days after AMI and reperfusion therapy were followed up for cardiac death (CD) and AMI. LV ejection fraction (LVEF), LV end-systolic volume (ESV), and LV end-diastolic volume were assessed by the two methods independently. Outcome data were obtained (mean 46 ± 16 months).There were 15 (17%) events (eight CDs and seven AMIs). LVEF and ESV with contrast echocardiography were found to be independent multivariable predictors of CD (P = 0.04 and P = 0.02, respectively) and CD or AMI (P = 0.02 and P = 0.01, respectively). Furthermore, LVEF and ESV with contrast echocardiography provided incremental information for the prediction of CD (P = 0.004 and P = 0.004, respectively) and CD or AMI (P = 0.02 and P = 0.03, respectively).
Conclusion: Contrast echocardiography provided improved prediction of outcome compared with unenhanced echocardiography following AMI.
Keywords: Contrast echocardiography; Unenhanced echocardiography; Acute myocardial infarction; Left ventricular remodelling
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