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European Journal of Echocardiography Advance Access originally published online on August 19, 2009
European Journal of Echocardiography 2009 10(7):826-832; doi:10.1093/ejechocard/jep083
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org

Non-invasive assessment of left ventricular relaxation during atrial fibrillation using mitral flow propagation velocity{dagger}

Junko Asada-Kamiguchi1, Tomotsugu Tabata2,*, Zoran B. Popovic1, Neil L. Greenberg1, Yong Jin Kim1, Mario J. Garcia1, Don W. Wallick1, Kent A. Mowrey1, Shaowei Zhuang1, Youhua Zhang1, Todor N. Mazgalev1, James D. Thomas1 and Richard A. Grimm1

1 Section of Cardiovascular Imaging, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
2 Department of Internal Medicine, Division of Cardiology, Second Hospital of the Fujita Health Science University, 3-6-10 Otobashi, Nakagawa, Nagoya 454-8509, Japan

Received 29 August 2008; accepted after revision 23 May 2009; online publish-ahead-of-print 19 August 2009.

* Corresponding author. Tel: +81 52 323 5656; fax: +81 52 323 6399. E-mail address: tommy{at}fujita-hu.ac.jp


  Abstract

Aims: To elucidate the usefulness of the early diastolic mitral flow propagation velocity (Vp) obtained from colour M-mode Doppler for non-invasively assessing left-ventricular (LV) relaxation during atrial fibrillation (AF).

Methods and results: Ten healthy adult dogs were studied to correlate Vp with the invasive minimum value of the first derivative of LV pressure decay (dP/dtmin) and the time constant of isovolumic LV pressure decay ({tau}) at baseline, during rapid and slow AF, and during AF after inducing myocardial infarction. There were significant positive and negative curvilinear relationships between Vp and dP/dtmin and {tau}, respectively, during rapid AF. After slowing the ventricular rate, the average value of Vp increased, while dP/dtmin increased and {tau} decreased. After inducing myocardial infarction, the average value of Vp decreased, while dP/dtmin decreased and {tau} increased.

Conclusion: The non-invasively obtained Vp evaluates LV relaxation even during AF regardless of ventricular rhythm or the presence of pathological changes.

Keywords: Mitral flow propagation velocity; Atrial fibrillation; The first derivative of left ventricular pressure decay; The time constant of isovolumic left ventricular pressure decay

{dagger} This work had been performed in The Cleveland Clinic Foundation. This work was presented in part at the American Heart Association Scientific Sessions, New Orleans, LA, 12–15 November 2000.


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