© 2000 by European Society of Cardiology
Copyright © 2000, The European Society of Cardiology
The Effect of Pacing-induced Heart Rate Variation on Longitudinal and Circumferential Regional Myocardial Function After Acute Beta-Blockade — a Cardiac Ultrasound Study
1Linköping Heart Center, University Hospital, Linköping, Sweden
2Department of Anaesthesia and Intensive Care, University Hospital, Linköping, Sweden
3Institute of Pathology, University of Heidelberg, Heidelberg, Germany
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Abstract |
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Aims: To evaluate the effect of acute beta-blockade in combination with differing heart rates on longitudinal and circumferential regional myocardial function using Doppler myocardial imaging and two-dimensional-echocardiography.
Methods and Results: In seven pigs the following echocardiographic indices were measured at baseline, after beta-blockade both without and with atrial pacing: wall thickening fraction, fractional shortening, myocardial peak systolic velocity, transmyocardial velocity gradient and systolic velocity time integral of the posterolateral wall in short-axis view; mitral valve plane excursion, myocardial peak systolic velocity and systolic velocity time integral of the posterolateral wall in an apical five-chamber view. Peak systolic velocities and velocity gradients decreased significantly following acute beta-blockade but no further decay occurred at high heart rate due to pacing. The velocity time integrals and mitral valve plane excursion showed a tendency to decrease following beta-blockade but only after pacing were they significantly reduced. The wall thickening fraction and fractional shortening showed a significant reduction after beta-blockade but no further decay after pacing.
Conclusions: Changes in systolic velocities and velocity gradients were independent of heart rate reduction under high dosage beta-blockade, whereas wall thickening fraction, mitral valve plane excursion and velocity time integrals changed due to pacing.
Keywords: doppler myocardial imaging; left ventricular function; beta-blockade; heart rate variation
* Address for correspondence: Jörg M. Strotmann, Medizinische Universitätsklinik, Josef Schneider-Str. 2, 97080 Würzburg, Germany.
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  M. Quintana, T. Gustafsson, P. Sundblad, and J. Langanger The effects of heart rate on myocardial velocity and atrio-ventricular displacement during exercise with and without beta-blockade: a tissue Doppler echocardiographic study Eur J Echocardiogr, March 1, 2005; 6(2): 127 - 133. [Abstract] [Full Text] [PDF]
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