Skip Navigation

European Journal of Echocardiography 2000 1(3):180-183; doi:10.1053/euje.2000.0037
© 2000 by European Society of Cardiology
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Cottin, Y.
Right arrow Articles by Wolf, J.-E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cottin, Y.
Right arrow Articles by Wolf, J.-E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2000, The European Society of Cardiology

Dobutamine Stress Echocardiography Identifies Anthracycline Cardiotoxicity

Y. Cottin1,*, I. L'huillier1, O. Casasnovas2, C. Geoffroy1, D. Caillot2, M. Zeller1, E. Solary2, H. Guy2 and J.-E. Wolf1

1Cardiology Department, Centre Hospitalier Universitaire, Dijon, France
2Haematology Department, Centre Hospitalier Universitaire, Dijon, France


  Abstract

Background: Anthracyclines are effective anti-cancer agents, but their therapeutic value is limited by their myocardial toxicity. We assessed the physiological responses of stress echocardiography at low doses of dobutamine (DSE) in patients treated with anthracycline.

Methods and Results: In a prospective study, 28 patients were studied before and 1 month after the end of chemotherapy. All patients had normal ejection fraction (EF) at rest before therapy and the mean dose of anthracycline was 212±15 mg/m2. Echocardiographic Doppler studies were performed before and during dobutamine infusion (5 and 10 µg/kg per min). Rest echocardiography demonstrated a significant decrease of EF between the two examinations in ejection fraction (67±3% vs. 61±3%, P<0·001). The increase of the EF during dobutamine infusion was higher after chemotherapy compared to the initial examination (19±3% vs. 29±3%: P<0·05). No difference in EF was observed at 10 µg/kg per min between before and after chemotherapy. In contrast, at rest no difference in diastolic parameters was observed between the two examinations. Moreover, a significant decrease of the peak E and the ratio E/A was observed during dobutamine infusion after chemotherapy (93±4 cm/s vs. 79±5 cm/s and 1·3±0·1 vs. 1·0±0·1, respectively;P<0·05).

Conclusion: Stress echocardiography may prove to be a sensitive technique and useful non-invasive approach for evaluating subclinical anthracycline cardiotoxicity.

Keywords: stress echocardiography; dobutamine; anthracycline; left ventricular function

* Address for correspondence: Dr Yves Cottin, Service de Cardiologie, Hopital du Bocage, Bd de lattre de Tassigny, 21034 Dijon, Cedex, France.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.